Department of OBGYN

Pamela Ann Moalli, MD, PhD

  • Professor, Department of Obstetrics, Gynecology & Reproductive Sciences
  • Division Director, Urogynecology & Pelvic Reconstructive Surgery
  • Associate Professor, McGowan Institute of Regenerative Medicine, University of Pittsburgh
  • Associate Professor, Clinical & Translational Research Institute
  • Fellowship Director, Female Pelvic Medicine & Reconstructive Surgery, UPMC Medical Education Program
  • Member, Magee-Women Research Institute
  • Professor, Department of Bioengineering, University of Pittsburgh

In addition to her research and clinical efforts (described below), Dr. Moalli is extensively involved in teaching college and medical students, graduate students, residents and clinical fellows. Her greatest teaching commitment is to the fellows in the Female Pelvic Medicine and Reconstructive Surgery Program at the University of Pittsburgh. As Director of the program, she is responsible for ensuring that the fellows have the appropriate training as clinicians, surgeons and researchers to rise to the top of their field.

Education & Training

  • Fellowship, Urogynecology and Reconstructive Pelvic Surgery, Magee-Womens Hospital of UPMC, 2000
  • Residency, Obstetrics & Gynecology, Magee Women's Hospital of UPMC, University of Pittsburgh, 1998
  • MD, Ph.D. in Molecular and Cellular Biology, Northwestern University, 1994

Representative Publications

  • Zong W, Stein S, Meyn L, Starcher B and Moalli PA. Alteration of vaginal elastin metabolism in women with pelvic organ prolapse. Obstet Gynecol, 2010 May: 115(5) 953-61. PMCID: PMC3042770
  • Alperin M, Feola A, Duerr R, Moalli PA, Abramowitch SD. Pregnancy- and delivery-induced biomechanical changes in rat vagina persist postpartum. Int Urogynecol J Pelvic Floor Dysfunct 2010 Sep;21(9):1169-74. Epub 2010 Apr 28. PMCID: PMC2939831
  • Alperin M, Feola A, Meyn LA, Duerr R, Abramowitch SD, Moalli P. Collagen scaffold: A treatment for simulated maternal birth injury in the rat model. Am J Obstet Gynecol. 2010 Jun;202(6):589.e1-589.e8. PMCID: PMC2921182.
  • Feola A, Abramowitch S, Jones K, Stein S, and Moalli P. Parity Negatively Impacts Vaginal Mechanical Properties and Collagen Structure in Rhesus Macaques. Am J Obstet Gynecol. 2010 Dec; 203(6):595.e1-8. Epub 2010 Aug 5. PMCID: PMC2993810

For additional publications, please see PubMed Page.

Clinical Interests/Research Interests

The primary focus of Dr. Moalli’s research has been on prolapse meshes – first defining their impact on the vagina and then transitioning to mechanisms of complications. Based on this knowledge, her group is developing novel elastomeric meshes whose properties more closely match those of the vagina. Recently, she has explored regenerative techniques to rebuild compromised vaginal supportive tissues. The strength of her research group is that it is highly interdisciplinary with expertise in biochemistry, biomechanics, computational analyses, and biomaterials. The expertise gained from this work has benefitted both the Urinary Incontinence Treatment Network and the Pelvic Floor Disorders Network. Currently, she is leading a national multicenter trial defining mechanisms of anterior vaginal wall failure following a native tissue versus a mesh augmented repair of uterovaginal prolapse.