Department of OBGYN

Judith L. Yanowitz, PhD

  • Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences

Education & Training

  • Postdoctoral Fellowship, Carnegie Institution for Science, Department of Embryology, Baltimore, MD, 2003
  • Ph.D., Princeton University, Princeton, NJ, 1999

Representative Publications

  • Amrit FR, Steenkiste EM, Ratnappan R, Chen SW, McClendon TB, Kostka D, Yanowitz J, Olsen CP, Ghazi A. DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans. PLoS¬†Genet. 2016;12(2):e1005788.
  • Hillers KJ, Jantsch V, Martinez-Perez E, Yanowitz JL. Meiosis. WormBook. 2015:1-54.
  • Mainpal R, Nance J, Yanowitz JL. A germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans. Development. 2015;142(20):3571-82.
  • Chung G, Rose AM, Petalcorin MI, Martin JS, Kessler Z, Sanchez-Pulido L, Ponting CP, Yanowitz JL, Boulton SJ. REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans. Genes Dev. 2015;29(18):1969-79.

For additional publications, see: (Pubmed or other online collection) http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&ter... OWITZ+J&log%24=activity

Clinical Interests/Research Interests

The Yanowitz lab aims to elucidate the mechanisms that underlie human reproductive aging. Defects in meiotic crossover recombination are a major determinant of chromosome mis-segregation during the formation of eggs and sperm. The lab addresses how meiosis is regulated using the nematode C. elegans, where the combination of genetic, molecular, and cytological tools facilitates the isolation and characterization of meiotic genes.