Department of OBGYN

Alexander N. Yatsenko, MD, PhD

  • Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences
  • Director, Pittsburgh Clinical Genomic Laboratory

Education & Training

  • ABMG Fellowship, Baylor College of Medicine, Houston, TX, USA
  • Postdoctorate, Baylor College of Medicine, Houston, TX, USA
  • PhD, Medical Genetics Scientific Center, Moscow, Russia
  • MD, Russian State Medical University, Moscow, Russia

Representative Publications

  • Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe TM, Olszewska M, Westernströer B, Sanfilippo JS, Kurpisz M, Rajkovic A, Yatsenko SA, Kliesch S, Schlatt S, Tuttelman F. X-linked TEX11mutations, meiotic arrest and azoospermia in infertile men. N Engl J Med. 2015;372(22):2097-107.
  • Georgiadis AP, Kishore A, Zorrilla M, Jaffe TM, Sanfilippo JS, Volk E, Rajkovic A, Yatsenko AN. High quality RNA in semen and sperm: Isolation, analysis and potential application in clinical testing. J Urol. 2015;193(1):352-9.
  • Wiland E, Olszewska M, Georgiadis A, Huleyuk N, Panasiuk B, Zastavna D, Yatsenko SA, Jedrzejczak P, Midro AT, Yatsenko AN, Kurpisz M. Cytogenetic and molecular analyses of de novo translocation dic(9;13)(p11.2;p12) in an infertile male. Mol Cytogenet. 2014;7(1):14.
  • Khan MJ, Pollock N, Jiang H, Castro C, Nazli R, Ahmed J, Basit S, Rajkovic A, Yatsenko AN. X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. Sci Rep. 2018 Nov 2;8(1):16280. doi: 10.1038/s41598-018-34262-5. PMID: 30389958; PMCID:PMC6214919.
  • Yatsenko AN, Turek PJ. Reproductive genetics and the aging male. J Assist Reprod Genet. 2018 Jun;35(6):933-941. doi: 10.1007/s10815-018-1148-y. Epub 2018 Mar 9. Review. PMID: 29524155; PMCID: PMC6030011.

    For additional publications, see: (Pubmed or other online collection)

Clinical Interests/Research Interests

Dr. Alexander Yatsenko’s research focuses on identifying specific genetic errors that cause irreversible infertility in men – infertility that in vitro fertilization treatment can’t solve for hopeful, would-be parents. His ultimate goal is to connect his laboratory research with his clinical work, creating a diagnostic test that can detect the genetic mutation causing this type of male infertility, which right now remains a mystery. The diagnostics will help provide future viable treatment solutions for individuals struggling with infertility.

In the lab, Dr. Yatsenko and team work to decipher the effects of gene mutations on mRNAs, proteins, and cell function. He and his laboratory have been productive in the identification and functional characterization of specific gene mutations affecting male reproductive function, with the aim of translating these findings to clinical practice.